Target name

P25116: Proteinase-activated receptor 1


  Protein function

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

  Database links

Uniprot primary ID P25116
GRCP SARfari Variant Name hPAR1_121
PDB ID 3LU9 1NRO 1NRN 3HKJ 1NRR 1NRQ 1NRP 3VW7 3BEF 3HKI
DrugBank ID DB00086
BioGrid ID 108448
GuidetoPHARMACOLOGY ID 347
PharmGKB ID PA27946
KEGG ID hsa:2149
Entrez Gene (Gene ID) 2149
BindingDB P25116

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.63 0.93 0.78 0.74 0.9 0.59 Download
FP4 fingerprints 0.630 0.840 0.740 0.700 0.830 0.480 Download
MACCS fingerprints 0.690 0.800 0.750 0.730 0.810 0.500 Download
Daylight fingerprints 0.650 0.940 0.790 0.760 0.890 0.610 Download
ECFP2 fingerprints 0.770 0.870 0.820 0.810 0.920 0.640 Download
ECFP4 fingerprints 0.860 0.870 0.870 0.860 0.950 0.730 Download
ECFP6 fingerprints 0.840 0.880 0.860 0.860 0.950 0.720 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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