Target name

P25929: Neuropeptide Y receptor type 1


  Protein function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

  Database links

Uniprot primary ID P25929
GRCP SARfari Variant Name hNPY1R_122
PDB ID 2F1U 2IIL
DrugBank ID
BioGrid ID 110946
GuidetoPHARMACOLOGY ID 305
PharmGKB ID PA258
KEGG ID hsa:4886
Entrez Gene (Gene ID) 4886
BindingDB P25929

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.71 0.86 0.78 0.77 0.83 0.57 Download
FP4 fingerprints 0.650 0.740 0.700 0.680 0.760 0.390 Download
MACCS fingerprints 0.780 0.700 0.740 0.750 0.800 0.480 Download
Daylight fingerprints 0.760 0.720 0.740 0.750 0.770 0.490 Download
ECFP2 fingerprints 0.730 0.890 0.810 0.790 0.830 0.620 Download
ECFP4 fingerprints 0.760 0.920 0.840 0.830 0.870 0.690 Download
ECFP6 fingerprints 0.740 0.930 0.830 0.820 0.860 0.680 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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