Target name

P26255: Beta-3 adrenergic receptor


  Protein function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

  Database links

Uniprot primary ID P26255
GRCP SARfari Variant Name rB3AR_1402
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 30
PharmGKB ID
KEGG ID rno:25645
Entrez Gene (Gene ID) 25645
BindingDB P26255

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.77 0.69 0.73 0.74 0.84 0.46 Download
FP4 fingerprints 0.780 0.670 0.720 0.740 0.760 0.450 Download
MACCS fingerprints 0.820 0.610 0.710 0.740 0.760 0.440 Download
Daylight fingerprints 0.770 0.670 0.720 0.730 0.760 0.440 Download
ECFP2 fingerprints 0.740 0.620 0.680 0.700 0.790 0.360 Download
ECFP4 fingerprints 0.850 0.730 0.790 0.800 0.860 0.580 Download
ECFP6 fingerprints 0.830 0.800 0.820 0.820 0.880 0.630 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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