Target name

P26684: Endothelin-1 receptor


  Protein function

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

  Database links

Uniprot primary ID P26684
GRCP SARfari Variant Name rETA_1403
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 219
PharmGKB ID
KEGG ID rno:24326
Entrez Gene (Gene ID) 24326
BindingDB P26684

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.8 0.9 0.85 0.85 0.93 0.71 Download
FP4 fingerprints 0.870 0.820 0.850 0.850 0.920 0.690 Download
MACCS fingerprints 0.880 0.830 0.850 0.860 0.910 0.710 Download
Daylight fingerprints 0.860 0.800 0.830 0.840 0.880 0.660 Download
ECFP2 fingerprints 0.950 0.870 0.910 0.910 0.960 0.820 Download
ECFP4 fingerprints 0.930 0.900 0.920 0.920 0.970 0.840 Download
ECFP6 fingerprints 0.910 0.920 0.910 0.910 0.970 0.830 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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