Target name

P28221: 5-hydroxytryptamine receptor 1D


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

  Database links

Uniprot primary ID P28221
GRCP SARfari Variant Name h5HT1D_123
PDB ID
DrugBank ID DB00953 DB00952 DB01049 DB00320 DB00321 DB00734 DB00918 DB01238 DB00998 DB00408 DB00268 DB00589 DB00669 DB01392 DB00216 DB00334 DB00315 DB00726 DB01186 DB01200 DB01267 DB00413 DB00696 DB01221 DB01224 DB00714 DB00363 DB00246 DB00248
BioGrid ID 109584
GuidetoPHARMACOLOGY ID 3
PharmGKB ID PA29550
KEGG ID hsa:3352
Entrez Gene (Gene ID) 3352
BindingDB P28221

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.77 0.78 0.78 0.77 0.85 0.55 Download
FP4 fingerprints 0.840 0.660 0.750 0.770 0.800 0.510 Download
MACCS fingerprints 0.740 0.670 0.700 0.710 0.770 0.410 Download
Daylight fingerprints 0.680 0.800 0.740 0.720 0.800 0.480 Download
ECFP2 fingerprints 0.880 0.730 0.800 0.820 0.880 0.610 Download
ECFP4 fingerprints 0.870 0.840 0.850 0.850 0.920 0.700 Download
ECFP6 fingerprints 0.800 0.870 0.840 0.830 0.920 0.670 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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