Target name

P28222: 5-hydroxytryptamine receptor 1B


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

  Database links

Uniprot primary ID P28222
GRCP SARfari Variant Name h5HT1B_124
PDB ID 2G1X 4IAR 4IAQ
DrugBank ID DB00953 DB00952 DB01049 DB08807 DB00320 DB00321 DB00918 DB06216 DB01359 DB01238 DB00268 DB00998 DB00408 DB00960 DB00543 DB00589 DB00669 DB01392 DB00216 DB00334 DB00315 DB00904 DB01186 DB01200 DB00413 DB00696 DB01221 DB01224 DB00714 DB00363 DB00247 DB00246 DB00571 DB00248
BioGrid ID 109583
GuidetoPHARMACOLOGY ID 2
PharmGKB ID PA29549
KEGG ID hsa:3351
Entrez Gene (Gene ID) 3351
BindingDB P28222

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.78 0.82 0.8 0.8 0.86 0.6 Download
FP4 fingerprints 0.850 0.700 0.780 0.790 0.830 0.560 Download
MACCS fingerprints 0.740 0.680 0.710 0.720 0.790 0.420 Download
Daylight fingerprints 0.630 0.840 0.740 0.710 0.830 0.480 Download
ECFP2 fingerprints 0.850 0.790 0.820 0.820 0.890 0.640 Download
ECFP4 fingerprints 0.840 0.870 0.860 0.850 0.920 0.710 Download
ECFP6 fingerprints 0.790 0.900 0.850 0.840 0.920 0.700 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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