Target name

P28223: 5-hydroxytryptamine receptor 2A


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca

  Database links

Uniprot primary ID P28223
GRCP SARfari Variant Name h5HT2A_125
PDB ID
DrugBank ID DB00751 DB00777 DB06148 DB01142 DB01049 DB01624 DB01622 DB01069 DB01149 DB01621 DB04842 DB00933 DB06288 DB00875 DB00502 DB09016 DB01239 DB01238 DB00268 DB00679 DB00934 DB00409 DB00408 DB00370 DB01403 DB00604 DB00540 DB00420 DB00589 DB00924 DB01614 DB01151 DB06216 DB08810 DB00334 DB01392 DB04946 DB00726 DB00321 DB00805 DB06144 DB01623 DB08815 DB01242 DB01618 DB01186 DB01200 DB01267 DB00458 DB00248 DB00413 DB00696 DB00477 DB01221 DB01224 DB00715 DB00714 DB00363 DB00247 DB00246 DB00434 DB00843 DB00543 DB00734 DB00656
BioGrid ID 109588
GuidetoPHARMACOLOGY ID 6
PharmGKB ID PA193
KEGG ID hsa:3356
Entrez Gene (Gene ID) 3356
BindingDB P28223

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.78 0.69 0.73 0.75 0.83 0.47 Download
FP4 fingerprints 0.810 0.700 0.750 0.770 0.810 0.510 Download
MACCS fingerprints 0.790 0.640 0.710 0.730 0.770 0.430 Download
Daylight fingerprints 0.660 0.680 0.670 0.660 0.730 0.340 Download
ECFP2 fingerprints 0.880 0.760 0.820 0.830 0.900 0.650 Download
ECFP4 fingerprints 0.870 0.820 0.840 0.850 0.930 0.690 Download
ECFP6 fingerprints 0.860 0.830 0.840 0.850 0.920 0.690 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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