Target name

P28335: 5-hydroxytryptamine receptor 2C

  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca

  Database links

Uniprot primary ID P28335
GRCP SARfari Variant Name h5HT2C_126
DrugBank ID DB00777 DB06148 DB01142 DB01049 DB00321 DB01149 DB00734 DB00934 DB01191 DB01239 DB01238 DB00268 DB00408 DB00370 DB01403 DB00540 DB00543 DB00589 DB01151 DB06216 DB00334 DB01392 DB00726 DB00805 DB06144 DB09014 DB01242 DB01186 DB01200 DB01267 DB00458 DB00248 DB00413 DB00696 DB00477 DB04871 DB01221 DB01224 DB00714 DB00363 DB00247 DB00246 DB00434 DB06594 DB00420 DB00193 DB00656
BioGrid ID 109590
PharmGKB ID PA194
KEGG ID hsa:3358
Entrez Gene (Gene ID) 3358
BindingDB P28335

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.72 0.72 0.72 0.72 0.81 0.44 Download
FP4 fingerprints 0.790 0.650 0.720 0.740 0.780 0.450 Download
MACCS fingerprints 0.760 0.610 0.680 0.710 0.740 0.370 Download
Daylight fingerprints 0.670 0.670 0.670 0.670 0.730 0.340 Download
ECFP2 fingerprints 0.850 0.750 0.800 0.810 0.880 0.600 Download
ECFP4 fingerprints 0.860 0.810 0.830 0.840 0.910 0.670 Download
ECFP6 fingerprints 0.820 0.820 0.820 0.820 0.900 0.640 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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