Target name

P28564: 5-hydroxytryptamine receptor 1B


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

  Database links

Uniprot primary ID P28564
GRCP SARfari Variant Name r5HT1B_1408
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 2
PharmGKB ID
KEGG ID rno:25075
Entrez Gene (Gene ID) 25075
BindingDB P28564

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.79 0.77 0.78 0.78 0.86 0.57 Download
FP4 fingerprints 0.740 0.670 0.700 0.710 0.790 0.410 Download
MACCS fingerprints 0.750 0.620 0.690 0.700 0.750 0.370 Download
Daylight fingerprints 0.710 0.710 0.710 0.710 0.750 0.410 Download
ECFP2 fingerprints 0.870 0.640 0.750 0.780 0.870 0.520 Download
ECFP4 fingerprints 0.900 0.750 0.830 0.840 0.920 0.660 Download
ECFP6 fingerprints 0.870 0.790 0.830 0.840 0.920 0.660 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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