Target name

P28565: 5-hydroxytryptamine receptor 1D


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

  Database links

Uniprot primary ID P28565
GRCP SARfari Variant Name r5HT1D_1409
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 3
PharmGKB ID
KEGG ID rno:25323
Entrez Gene (Gene ID) 25323
BindingDB P28565

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.81 0.77 0.79 0.8 0.88 0.58 Download
FP4 fingerprints 0.830 0.690 0.760 0.780 0.820 0.520 Download
MACCS fingerprints 0.750 0.700 0.730 0.730 0.790 0.450 Download
Daylight fingerprints 0.670 0.780 0.730 0.710 0.810 0.460 Download
ECFP2 fingerprints 0.860 0.740 0.800 0.810 0.900 0.600 Download
ECFP4 fingerprints 0.920 0.850 0.890 0.890 0.940 0.780 Download
ECFP6 fingerprints 0.880 0.880 0.880 0.880 0.940 0.750 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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