Target name

P28566: 5-hydroxytryptamine receptor 1E


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

  Database links

Uniprot primary ID P28566
GRCP SARfari Variant Name h5HT1E_128
PDB ID
DrugBank ID DB01221 DB01238 DB01049 DB00216 DB00334 DB01224 DB00408 DB00363 DB00247 DB00246
BioGrid ID 109586
GuidetoPHARMACOLOGY ID 4
PharmGKB ID PA29552
KEGG ID hsa:3354
Entrez Gene (Gene ID) 3354
BindingDB P28566

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.6 0.81 0.71 0.67 0.76 0.42 Download
FP4 fingerprints 0.580 0.500 0.540 0.560 0.610 0.090 Download
MACCS fingerprints 0.470 0.910 0.690 0.600 0.700 0.420 Download
Daylight fingerprints 0.570 0.680 0.630 0.610 0.650 0.260 Download
ECFP2 fingerprints 0.550 0.540 0.540 0.540 0.590 0.090 Download
ECFP4 fingerprints 0.640 0.710 0.680 0.660 0.760 0.350 Download
ECFP6 fingerprints 0.650 0.740 0.700 0.680 0.790 0.390 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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