Target name

P29274: Adenosine receptor A2a


  Protein function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

  Database links

Uniprot primary ID P29274
GRCP SARfari Variant Name hAA2A_129
PDB ID 4UG2 3EML 3QAK 1UPE 3PWH 1MMH 3VGA 4UHR 2YDO 3REY 3VG9 2YDV 4EIY 3RFM 3UZC 3UZA
DrugBank ID DB00651 DB00640 DB06213 DB01412 DB00201 DB00824 DB00806 DB00358 DB04932 DB01303 DB00277
BioGrid ID 106647
GuidetoPHARMACOLOGY ID 19
PharmGKB ID PA24584
KEGG ID hsa:135
Entrez Gene (Gene ID) 135
BindingDB P29274

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.89 0.77 0.83 0.84 0.88 0.66 Download
FP4 fingerprints 0.860 0.710 0.790 0.800 0.860 0.580 Download
MACCS fingerprints 0.880 0.730 0.810 0.820 0.850 0.620 Download
Daylight fingerprints 0.780 0.740 0.760 0.760 0.800 0.520 Download
ECFP2 fingerprints 0.940 0.760 0.850 0.860 0.900 0.720 Download
ECFP4 fingerprints 0.910 0.820 0.860 0.870 0.920 0.730 Download
ECFP6 fingerprints 0.870 0.830 0.850 0.860 0.910 0.710 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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