Target name

P29371: Neuromedin-K receptor


  Protein function

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

  Database links

Uniprot primary ID P29371
GRCP SARfari Variant Name hNK3R_131
PDB ID
DrugBank ID
BioGrid ID 112733
GuidetoPHARMACOLOGY ID 362
PharmGKB ID PA36304
KEGG ID hsa:6870
Entrez Gene (Gene ID) 6870
BindingDB P29371

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.86 0.92 0.89 0.89 0.96 0.78 Download
FP4 fingerprints 0.920 0.770 0.850 0.860 0.890 0.700 Download
MACCS fingerprints 0.820 0.840 0.830 0.830 0.910 0.660 Download
Daylight fingerprints 0.740 0.930 0.830 0.820 0.890 0.680 Download
ECFP2 fingerprints 0.900 0.920 0.910 0.910 0.950 0.820 Download
ECFP4 fingerprints 0.920 0.960 0.940 0.940 0.970 0.870 Download
ECFP6 fingerprints 0.890 0.970 0.930 0.930 0.970 0.860 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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