Target name

P30518: Vasopressin V2 receptor


  Protein function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.

  Database links

Uniprot primary ID P30518
GRCP SARfari Variant Name hV2R_134
PDB ID 4JQI
DrugBank ID DB02638 DB06212 DB00035 DB00067 DB00872
BioGrid ID 107035
GuidetoPHARMACOLOGY ID 368
PharmGKB ID PA25189
KEGG ID hsa:554
Entrez Gene (Gene ID) 554
BindingDB P30518

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.78 0.91 0.85 0.83 0.91 0.7 Download
FP4 fingerprints 0.880 0.820 0.850 0.860 0.900 0.710 Download
MACCS fingerprints 0.790 0.850 0.820 0.820 0.880 0.640 Download
Daylight fingerprints 0.770 0.900 0.840 0.830 0.890 0.680 Download
ECFP2 fingerprints 0.880 0.910 0.890 0.890 0.930 0.790 Download
ECFP4 fingerprints 0.880 0.940 0.910 0.910 0.940 0.820 Download
ECFP6 fingerprints 0.880 0.950 0.910 0.910 0.950 0.830 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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