Target name

P30551: Cholecystokinin receptor type A


  Protein function

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P30551
GRCP SARfari Variant Name rCCKAR_1422
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 76
PharmGKB ID
KEGG ID rno:24889
Entrez Gene (Gene ID) 24889
BindingDB P30551

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.84 0.79 0.81 0.82 0.87 0.63 Download
FP4 fingerprints 0.860 0.790 0.820 0.830 0.890 0.640 Download
MACCS fingerprints 0.900 0.760 0.830 0.840 0.880 0.660 Download
Daylight fingerprints 0.850 0.770 0.810 0.820 0.840 0.630 Download
ECFP2 fingerprints 0.910 0.830 0.870 0.870 0.920 0.740 Download
ECFP4 fingerprints 0.910 0.840 0.880 0.880 0.930 0.760 Download
ECFP6 fingerprints 0.880 0.850 0.870 0.870 0.930 0.730 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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