Target name

P30553: Gastrin/cholecystokinin type B receptor


  Protein function

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P30553
GRCP SARfari Variant Name rCCKBR_1424
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 77
PharmGKB ID
KEGG ID rno:25706
Entrez Gene (Gene ID) 25706
BindingDB P30553

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.84 0.66 0.75 0.77 0.84 0.5 Download
FP4 fingerprints 0.890 0.640 0.760 0.790 0.830 0.540 Download
MACCS fingerprints 0.780 0.660 0.720 0.740 0.810 0.440 Download
Daylight fingerprints 0.820 0.660 0.740 0.760 0.780 0.490 Download
ECFP2 fingerprints 0.740 0.790 0.760 0.750 0.870 0.520 Download
ECFP4 fingerprints 0.810 0.850 0.830 0.830 0.910 0.660 Download
ECFP6 fingerprints 0.740 0.880 0.810 0.790 0.920 0.630 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn