Target name

P30557: Prostaglandin E2 receptor EP3 subtype


  Protein function

Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium. The various forms can interact with different second messenger systems.

  Database links

Uniprot primary ID P30557
GRCP SARfari Variant Name mPTGER3_1426
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 342
PharmGKB ID
KEGG ID
Entrez Gene (Gene ID)
BindingDB P30557

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.9 0.92 0.91 0.91 0.96 0.82 Download
FP4 fingerprints 0.810 0.850 0.830 0.820 0.920 0.650 Download
MACCS fingerprints 0.820 0.820 0.820 0.820 0.920 0.630 Download
Daylight fingerprints 0.690 0.960 0.830 0.800 0.920 0.680 Download
ECFP2 fingerprints 0.940 0.890 0.910 0.920 0.970 0.830 Download
ECFP4 fingerprints 0.940 0.950 0.950 0.950 0.980 0.890 Download
ECFP6 fingerprints 0.910 0.950 0.930 0.930 0.980 0.860 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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