Target name

P30729: D(4) dopamine receptor


  Protein function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells which in turn regulates the rhythmic expression of the ADCY1 gene in the ganglian cell layer (By similarity).

  Database links

Uniprot primary ID P30729
GRCP SARfari Variant Name rDRD4_1431
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 217
PharmGKB ID
KEGG ID rno:25432
Entrez Gene (Gene ID)
BindingDB P30729

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.9 0.74 0.82 0.83 0.88 0.65 Download
FP4 fingerprints 0.840 0.710 0.770 0.790 0.840 0.550 Download
MACCS fingerprints 0.850 0.680 0.760 0.780 0.840 0.530 Download
Daylight fingerprints 0.850 0.640 0.750 0.770 0.800 0.500 Download
ECFP2 fingerprints 0.940 0.750 0.840 0.860 0.920 0.700 Download
ECFP4 fingerprints 0.940 0.820 0.880 0.890 0.940 0.770 Download
ECFP6 fingerprints 0.920 0.860 0.890 0.890 0.940 0.780 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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