Target name

P30874: Somatostatin receptor type 2


  Protein function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

  Database links

Uniprot primary ID P30874
GRCP SARfari Variant Name hSSTR2_140
PDB ID
DrugBank ID DB00104 DB06663 DB04894
BioGrid ID 112630
GuidetoPHARMACOLOGY ID 356
PharmGKB ID PA36155
KEGG ID hsa:6752
Entrez Gene (Gene ID) 6752
BindingDB P30874

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.88 0.91 0.89 0.89 0.93 0.79 Download
FP4 fingerprints 0.880 0.940 0.910 0.910 0.940 0.820 Download
MACCS fingerprints 0.840 0.920 0.880 0.880 0.920 0.770 Download
Daylight fingerprints 0.870 0.910 0.890 0.890 0.920 0.790 Download
ECFP2 fingerprints 0.880 0.930 0.900 0.900 0.960 0.810 Download
ECFP4 fingerprints 0.860 0.950 0.900 0.900 0.960 0.810 Download
ECFP6 fingerprints 0.810 0.950 0.880 0.880 0.960 0.780 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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