Target name

P30937: Somatostatin receptor type 4


  Protein function

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.

  Database links

Uniprot primary ID P30937
GRCP SARfari Variant Name rSSTR4_1438
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 358
PharmGKB ID
KEGG ID rno:25555
Entrez Gene (Gene ID) 25555
BindingDB P30937

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.98 0.85 0.91 0.92 0.94 0.84 Download
FP4 fingerprints 0.980 0.850 0.910 0.920 0.930 0.840 Download
MACCS fingerprints 0.980 0.870 0.930 0.930 0.940 0.860 Download
Daylight fingerprints 0.950 0.870 0.910 0.910 0.930 0.820 Download
ECFP2 fingerprints 0.960 0.850 0.910 0.910 0.940 0.820 Download
ECFP4 fingerprints 0.950 0.900 0.930 0.930 0.950 0.860 Download
ECFP6 fingerprints 0.950 0.910 0.930 0.930 0.950 0.860 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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