Target name

P30939: 5-hydroxytryptamine receptor 1F


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

  Database links

Uniprot primary ID P30939
GRCP SARfari Variant Name h5HT1F_141
PDB ID
DrugBank ID DB00953 DB00952 DB06148 DB00696 DB01049 DB00669 DB00216 DB01221 DB00315 DB00247
BioGrid ID
GuidetoPHARMACOLOGY ID 5
PharmGKB ID PA29553
KEGG ID hsa:3355
Entrez Gene (Gene ID) 3355
BindingDB P30939

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.84 0.9 0.87 0.87 0.92 0.74 Download
FP4 fingerprints 0.850 0.760 0.810 0.820 0.900 0.620 Download
MACCS fingerprints 0.800 0.800 0.800 0.800 0.880 0.600 Download
Daylight fingerprints 0.660 0.970 0.810 0.780 0.900 0.660 Download
ECFP2 fingerprints 0.830 0.800 0.820 0.820 0.900 0.630 Download
ECFP4 fingerprints 0.830 0.900 0.860 0.860 0.940 0.730 Download
ECFP6 fingerprints 0.810 0.940 0.870 0.860 0.940 0.750 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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