Target name

P30940: 5-hydroxytryptamine receptor 1F


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

  Database links

Uniprot primary ID P30940
GRCP SARfari Variant Name r5HT1F_1440
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 5
PharmGKB ID
KEGG ID
Entrez Gene (Gene ID)
BindingDB P30940

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.83 0.76 0.8 0.81 0.88 0.6 Download
FP4 fingerprints 0.830 0.670 0.750 0.770 0.810 0.510 Download
MACCS fingerprints 0.700 0.680 0.690 0.700 0.800 0.390 Download
Daylight fingerprints 0.700 0.730 0.720 0.710 0.800 0.440 Download
ECFP2 fingerprints 0.880 0.700 0.790 0.800 0.890 0.580 Download
ECFP4 fingerprints 0.910 0.790 0.850 0.860 0.940 0.710 Download
ECFP6 fingerprints 0.870 0.840 0.860 0.860 0.930 0.720 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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