Target name

P30968: Gonadotropin-releasing hormone receptor


  Protein function

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform

  Database links

Uniprot primary ID P30968
GRCP SARfari Variant Name hGNRHR_142
PDB ID
DrugBank ID DB00106 DB00644 DB00666 DB01406 DB00050 DB06699 DB06719 DB00007 DB00014
BioGrid ID 109060
GuidetoPHARMACOLOGY ID 256
PharmGKB ID PA28800
KEGG ID hsa:2798
Entrez Gene (Gene ID) 2798
BindingDB P30968

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.74 0.92 0.83 0.82 0.92 0.68 Download
FP4 fingerprints 0.760 0.850 0.810 0.800 0.900 0.620 Download
MACCS fingerprints 0.850 0.810 0.830 0.830 0.900 0.660 Download
Daylight fingerprints 0.770 0.810 0.790 0.790 0.860 0.580 Download
ECFP2 fingerprints 0.900 0.930 0.920 0.920 0.960 0.840 Download
ECFP4 fingerprints 0.950 0.940 0.940 0.940 0.970 0.890 Download
ECFP6 fingerprints 0.930 0.940 0.940 0.940 0.970 0.870 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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