Target name

P30969: Gonadotropin-releasing hormone receptor


  Protein function

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P30969
GRCP SARfari Variant Name rGNRHR_1443
PDB ID
DrugBank ID
BioGrid ID 249567
GuidetoPHARMACOLOGY ID 256
PharmGKB ID
KEGG ID rno:81668
Entrez Gene (Gene ID) 81668
BindingDB P30969

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.78 0.9 0.84 0.83 0.93 0.68 Download
FP4 fingerprints 0.830 0.860 0.850 0.840 0.920 0.690 Download
MACCS fingerprints 0.790 0.860 0.830 0.820 0.910 0.650 Download
Daylight fingerprints 0.800 0.850 0.830 0.820 0.900 0.660 Download
ECFP2 fingerprints 0.800 0.910 0.860 0.850 0.940 0.720 Download
ECFP4 fingerprints 0.840 0.930 0.890 0.880 0.960 0.780 Download
ECFP6 fingerprints 0.820 0.940 0.880 0.870 0.960 0.760 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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