Target name

P30989: Neurotensin receptor type 1


  Protein function

G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.

  Database links

Uniprot primary ID P30989
GRCP SARfari Variant Name hNTSR1_143
PDB ID 2LYW
DrugBank ID
BioGrid ID 110977
GuidetoPHARMACOLOGY ID 309
PharmGKB ID PA31821
KEGG ID hsa:4923
Entrez Gene (Gene ID) 4923
BindingDB P30989

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.62 0.92 0.77 0.73 0.78 0.57 Download
FP4 fingerprints 0.580 0.900 0.740 0.690 0.740 0.510 Download
MACCS fingerprints 0.580 0.910 0.740 0.690 0.740 0.510 Download
Daylight fingerprints 0.560 0.980 0.770 0.700 0.760 0.590 Download
ECFP2 fingerprints 0.580 0.960 0.770 0.720 0.710 0.590 Download
ECFP4 fingerprints 0.600 0.980 0.790 0.740 0.780 0.620 Download
ECFP6 fingerprints 0.600 0.980 0.790 0.740 0.790 0.620 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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