Target name

P30994: 5-hydroxytryptamine receptor 2B


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca

  Database links

Uniprot primary ID P30994
GRCP SARfari Variant Name r5HT2B_1446
PDB ID
DrugBank ID
BioGrid ID 248214
GuidetoPHARMACOLOGY ID 7
PharmGKB ID
KEGG ID rno:29581
Entrez Gene (Gene ID) 29581
BindingDB P30994

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.83 0.74 0.78 0.79 0.88 0.57 Download
FP4 fingerprints 0.870 0.720 0.790 0.810 0.870 0.590 Download
MACCS fingerprints 0.800 0.670 0.740 0.750 0.810 0.480 Download
Daylight fingerprints 0.800 0.760 0.780 0.780 0.860 0.560 Download
ECFP2 fingerprints 0.840 0.820 0.830 0.830 0.920 0.660 Download
ECFP4 fingerprints 0.880 0.880 0.880 0.880 0.950 0.750 Download
ECFP6 fingerprints 0.830 0.890 0.860 0.860 0.950 0.720 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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