Target name

P31389: Histamine H1 receptor


  Protein function

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

  Database links

Uniprot primary ID P31389
GRCP SARfari Variant Name cavHRH1_1448
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
Entrez Gene (Gene ID)
BindingDB P31389

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.82 0.97 0.9 0.89 0.93 0.8 Download
FP4 fingerprints 0.870 0.870 0.870 0.870 0.930 0.740 Download
MACCS fingerprints 0.860 0.790 0.820 0.830 0.920 0.650 Download
Daylight fingerprints 0.740 0.990 0.860 0.840 0.900 0.750 Download
ECFP2 fingerprints 0.840 0.830 0.840 0.840 0.930 0.680 Download
ECFP4 fingerprints 0.850 0.920 0.890 0.880 0.950 0.770 Download
ECFP6 fingerprints 0.810 0.980 0.890 0.880 0.960 0.800 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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