Target name

P31390: Histamine H1 receptor


  Protein function

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

  Database links

Uniprot primary ID P31390
GRCP SARfari Variant Name rHRH1_1449
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 262
PharmGKB ID
KEGG ID rno:24448
Entrez Gene (Gene ID) 24448
BindingDB P31390

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.84 0.84 0.84 0.84 0.89 0.68 Download
FP4 fingerprints 0.860 0.570 0.710 0.750 0.780 0.450 Download
MACCS fingerprints 0.860 0.780 0.820 0.830 0.880 0.640 Download
Daylight fingerprints 0.800 0.770 0.780 0.790 0.840 0.560 Download
ECFP2 fingerprints 0.910 0.720 0.820 0.830 0.880 0.640 Download
ECFP4 fingerprints 0.930 0.820 0.870 0.880 0.930 0.750 Download
ECFP6 fingerprints 0.930 0.870 0.900 0.900 0.930 0.800 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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