Target name

P31391: Somatostatin receptor type 4


  Protein function

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

  Database links

Uniprot primary ID P31391
GRCP SARfari Variant Name hSSTR4_145
PDB ID
DrugBank ID
BioGrid ID 112632
GuidetoPHARMACOLOGY ID 358
PharmGKB ID PA36157
KEGG ID hsa:6754
Entrez Gene (Gene ID) 6754
BindingDB P31391

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.85 0.91 0.88 0.88 0.93 0.76 Download
FP4 fingerprints 0.870 0.940 0.900 0.900 0.940 0.810 Download
MACCS fingerprints 0.840 0.930 0.890 0.880 0.920 0.770 Download
Daylight fingerprints 0.850 0.910 0.880 0.880 0.910 0.760 Download
ECFP2 fingerprints 0.840 0.930 0.890 0.880 0.960 0.780 Download
ECFP4 fingerprints 0.830 0.950 0.890 0.890 0.960 0.790 Download
ECFP6 fingerprints 0.810 0.960 0.880 0.870 0.960 0.770 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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