Target name

P32238: Cholecystokinin receptor type A


  Protein function

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P32238
GRCP SARfari Variant Name hCCKAR_146
PDB ID 1D6G 1HZN 1PB2
DrugBank ID DB00403
BioGrid ID 107328
GuidetoPHARMACOLOGY ID 76
PharmGKB ID PA26142
KEGG ID hsa:886
Entrez Gene (Gene ID) 886
BindingDB P32238

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.82 0.86 0.84 0.83 0.89 0.68 Download
FP4 fingerprints 0.830 0.820 0.820 0.820 0.900 0.650 Download
MACCS fingerprints 0.770 0.800 0.790 0.790 0.860 0.580 Download
Daylight fingerprints 0.740 0.830 0.780 0.770 0.850 0.570 Download
ECFP2 fingerprints 0.800 0.870 0.840 0.830 0.920 0.680 Download
ECFP4 fingerprints 0.840 0.900 0.870 0.870 0.940 0.750 Download
ECFP6 fingerprints 0.800 0.920 0.860 0.850 0.940 0.720 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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