Target name

P32239: Gastrin/cholecystokinin type B receptor


  Protein function

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P32239
GRCP SARfari Variant Name hCCKBR_147
PDB ID 1L4T
DrugBank ID DB00183
BioGrid ID 107329
GuidetoPHARMACOLOGY ID 77
PharmGKB ID PA26143
KEGG ID hsa:887
Entrez Gene (Gene ID) 887
BindingDB P32239

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.91 0.74 0.83 0.84 0.88 0.66 Download
FP4 fingerprints 0.870 0.770 0.820 0.820 0.880 0.640 Download
MACCS fingerprints 0.900 0.760 0.830 0.840 0.890 0.670 Download
Daylight fingerprints 0.830 0.770 0.800 0.810 0.860 0.600 Download
ECFP2 fingerprints 0.910 0.820 0.860 0.870 0.920 0.730 Download
ECFP4 fingerprints 0.920 0.860 0.890 0.890 0.940 0.780 Download
ECFP6 fingerprints 0.900 0.870 0.880 0.890 0.940 0.770 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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