Target name

P32240: Prostaglandin E2 receptor EP4 subtype


  Protein function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

  Database links

Uniprot primary ID P32240
GRCP SARfari Variant Name mPTGER4_1452
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 343
PharmGKB ID
KEGG ID
Entrez Gene (Gene ID) 19219
BindingDB P32240

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.82 0.77 0.79 0.8 0.87 0.59 Download
FP4 fingerprints 0.810 0.760 0.780 0.790 0.830 0.570 Download
MACCS fingerprints 0.780 0.760 0.770 0.770 0.840 0.540 Download
Daylight fingerprints 0.800 0.840 0.820 0.810 0.840 0.640 Download
ECFP2 fingerprints 0.790 0.690 0.740 0.750 0.870 0.480 Download
ECFP4 fingerprints 0.830 0.870 0.850 0.850 0.900 0.700 Download
ECFP6 fingerprints 0.840 0.890 0.860 0.860 0.910 0.730 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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