Target name

P32245: Melanocortin receptor 4


  Protein function

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

  Database links

Uniprot primary ID P32245
GRCP SARfari Variant Name hMC4R_148
PDB ID 2IQP 2IQR 2IQS 2IQU 2IQV 2IQW
DrugBank ID
BioGrid ID 110330
GuidetoPHARMACOLOGY ID 285
PharmGKB ID PA30676
KEGG ID hsa:4160
Entrez Gene (Gene ID) 4160
BindingDB P32245

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.86 0.78 0.82 0.83 0.9 0.64 Download
FP4 fingerprints 0.830 0.790 0.810 0.810 0.880 0.620 Download
MACCS fingerprints 0.830 0.740 0.790 0.800 0.880 0.580 Download
Daylight fingerprints 0.800 0.840 0.820 0.810 0.860 0.640 Download
ECFP2 fingerprints 0.880 0.850 0.860 0.870 0.930 0.730 Download
ECFP4 fingerprints 0.870 0.880 0.870 0.870 0.950 0.750 Download
ECFP6 fingerprints 0.850 0.890 0.870 0.870 0.940 0.740 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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