Target name

P32246: C-C chemokine receptor type 1


  Protein function

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

  Database links

Uniprot primary ID P32246
GRCP SARfari Variant Name hCCR1_149
PDB ID 1Y5D
DrugBank ID
BioGrid ID 107635
GuidetoPHARMACOLOGY ID 58
PharmGKB ID PA26166
KEGG ID hsa:1230
Entrez Gene (Gene ID) 1230
BindingDB P32246

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.77 0.79 0.78 0.78 0.88 0.56 Download
FP4 fingerprints 0.710 0.760 0.740 0.730 0.830 0.470 Download
MACCS fingerprints 0.670 0.810 0.740 0.720 0.820 0.480 Download
Daylight fingerprints 0.770 0.870 0.820 0.810 0.870 0.650 Download
ECFP2 fingerprints 0.830 0.860 0.850 0.840 0.920 0.690 Download
ECFP4 fingerprints 0.900 0.890 0.900 0.900 0.950 0.790 Download
ECFP6 fingerprints 0.880 0.910 0.900 0.900 0.950 0.790 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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