Target name

P32300: Delta-type opioid receptor


  Protein function

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

  Database links

Uniprot primary ID P32300
GRCP SARfari Variant Name mOPRD1_1455
PDB ID 4EJ4
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 317
PharmGKB ID
KEGG ID mmu:18386
Entrez Gene (Gene ID) 18386
BindingDB P32300

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.83 0.69 0.76 0.78 0.83 0.53 Download
FP4 fingerprints 0.840 0.730 0.790 0.800 0.850 0.580 Download
MACCS fingerprints 0.770 0.690 0.730 0.740 0.810 0.460 Download
Daylight fingerprints 0.570 0.790 0.680 0.640 0.800 0.380 Download
ECFP2 fingerprints 0.860 0.760 0.810 0.820 0.890 0.630 Download
ECFP4 fingerprints 0.850 0.810 0.830 0.830 0.900 0.660 Download
ECFP6 fingerprints 0.780 0.840 0.810 0.800 0.900 0.620 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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