Target name

P32305: 5-hydroxytryptamine receptor 7


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. This receptor is implicated in the regulation of mammalian circadian rhythms.

  Database links

Uniprot primary ID P32305
GRCP SARfari Variant Name r5HT7_1457
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 12
PharmGKB ID
KEGG ID rno:103694905,rno:65032
Entrez Gene (Gene ID) 1.0369490565e+013
BindingDB P32305

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.86 0.77 0.82 0.83 0.91 0.64 Download
FP4 fingerprints 0.870 0.750 0.810 0.820 0.880 0.620 Download
MACCS fingerprints 0.810 0.720 0.770 0.780 0.850 0.530 Download
Daylight fingerprints 0.730 0.750 0.740 0.740 0.790 0.480 Download
ECFP2 fingerprints 0.890 0.770 0.830 0.840 0.920 0.670 Download
ECFP4 fingerprints 0.900 0.860 0.880 0.880 0.950 0.750 Download
ECFP6 fingerprints 0.850 0.900 0.880 0.870 0.950 0.750 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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