Target name

P33032: Melanocortin receptor 5


  Protein function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

  Database links

Uniprot primary ID P33032
GRCP SARfari Variant Name hMC5R_155
PDB ID
DrugBank ID
BioGrid ID 110331
GuidetoPHARMACOLOGY ID 286
PharmGKB ID PA30677
KEGG ID hsa:4161
Entrez Gene (Gene ID) 4161
BindingDB P33032

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.82 0.78 0.8 0.8 0.84 0.6 Download
FP4 fingerprints 0.830 0.680 0.760 0.770 0.840 0.520 Download
MACCS fingerprints 0.810 0.770 0.790 0.800 0.850 0.590 Download
Daylight fingerprints 0.770 0.800 0.780 0.780 0.810 0.570 Download
ECFP2 fingerprints 0.800 0.810 0.800 0.800 0.840 0.610 Download
ECFP4 fingerprints 0.800 0.830 0.820 0.810 0.860 0.630 Download
ECFP6 fingerprints 0.790 0.860 0.830 0.820 0.860 0.650 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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