Target name

P33033: Melanocortin receptor 3


  Protein function

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain (PubMed:

  Database links

Uniprot primary ID P33033
GRCP SARfari Variant Name mMC3R_1459
PDB ID
DrugBank ID
BioGrid ID 201340
GuidetoPHARMACOLOGY ID 284
PharmGKB ID
KEGG ID mmu:17201
Entrez Gene (Gene ID) 17201
BindingDB P33033

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.85 0.47 0.66 0.71 0.69 0.35 Download
FP4 fingerprints 0.830 0.410 0.620 0.680 0.540 0.260 Download
MACCS fingerprints 0.860 0.520 0.690 0.730 0.760 0.400 Download
Daylight fingerprints 0.810 0.580 0.700 0.730 0.710 0.410 Download
ECFP2 fingerprints 0.570 0.460 0.510 0.540 0.570 0.030 Download
ECFP4 fingerprints 0.610 0.640 0.630 0.620 0.700 0.250 Download
ECFP6 fingerprints 0.630 0.740 0.680 0.670 0.740 0.370 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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