Target name

P33534: Kappa-type opioid receptor


  Protein function

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

  Database links

Uniprot primary ID P33534
GRCP SARfari Variant Name mOPRK1_1461
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 318
PharmGKB ID
KEGG ID mmu:18387
Entrez Gene (Gene ID) 18387
BindingDB P33534

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.91 0.8 0.86 0.86 0.88 0.72 Download
FP4 fingerprints 0.870 0.740 0.810 0.820 0.860 0.620 Download
MACCS fingerprints 0.860 0.740 0.800 0.810 0.840 0.610 Download
Daylight fingerprints 0.690 0.860 0.780 0.760 0.830 0.560 Download
ECFP2 fingerprints 0.890 0.790 0.840 0.850 0.880 0.690 Download
ECFP4 fingerprints 0.920 0.830 0.880 0.880 0.920 0.760 Download
ECFP6 fingerprints 0.910 0.850 0.880 0.880 0.930 0.760 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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