Target name

P34969: 5-hydroxytryptamine receptor 7


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

  Database links

Uniprot primary ID P34969
GRCP SARfari Variant Name h5HT7_157
PDB ID
DrugBank ID DB00751 DB06148 DB01049 DB00321 DB06288 DB04946 DB01238 DB00934 DB00408 DB00370 DB00543 DB00216 DB00334 DB06216 DB08815 DB01200 DB00458 DB00477 DB00988 DB01224 DB00363 DB00247 DB00246 DB00248
BioGrid ID 109595
GuidetoPHARMACOLOGY ID 12
PharmGKB ID PA29561
KEGG ID hsa:3363
Entrez Gene (Gene ID) 3363
BindingDB P34969

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.75 0.81 0.78 0.78 0.86 0.56 Download
FP4 fingerprints 0.810 0.740 0.770 0.780 0.830 0.550 Download
MACCS fingerprints 0.720 0.700 0.710 0.710 0.780 0.420 Download
Daylight fingerprints 0.750 0.700 0.730 0.730 0.790 0.450 Download
ECFP2 fingerprints 0.870 0.780 0.820 0.830 0.900 0.650 Download
ECFP4 fingerprints 0.860 0.860 0.860 0.860 0.930 0.730 Download
ECFP6 fingerprints 0.800 0.890 0.840 0.840 0.920 0.690 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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