Target name

P34995: Prostaglandin E2 receptor EP1 subtype


  Protein function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

  Database links

Uniprot primary ID P34995
GRCP SARfari Variant Name hPTGER1_160
PDB ID
DrugBank ID DB01088 DB00770 DB00297 DB00429 DB00917 DB00905
BioGrid ID 111703
GuidetoPHARMACOLOGY ID 340
PharmGKB ID PA286
KEGG ID hsa:5731
Entrez Gene (Gene ID) 5731
BindingDB P34995

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.84 0.93 0.88 0.88 0.95 0.77 Download
FP4 fingerprints 0.880 0.840 0.860 0.860 0.940 0.720 Download
MACCS fingerprints 0.850 0.840 0.850 0.850 0.920 0.700 Download
Daylight fingerprints 0.790 0.880 0.840 0.830 0.890 0.670 Download
ECFP2 fingerprints 0.890 0.890 0.890 0.890 0.960 0.780 Download
ECFP4 fingerprints 0.880 0.940 0.910 0.910 0.970 0.820 Download
ECFP6 fingerprints 0.870 0.960 0.910 0.910 0.960 0.830 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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