Target name

P35348: Alpha-1A adrenergic receptor


  Protein function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

  Database links

Uniprot primary ID P35348
GRCP SARfari Variant Name hA1AA_162
PDB ID
DrugBank ID DB00751 DB00777 DB06148 DB00598 DB01142 DB01049 DB00610 DB06707 DB06207 DB00590 DB01622 DB01069 DB01149 DB00734 DB00696 DB01614 DB00388 DB00363 DB06694 DB01576 DB00935 DB06262 DB00875 DB04946 DB00449 DB01238 DB00831 DB00215 DB00679 DB00852 DB00934 DB01364 DB00408 DB00370 DB01136 DB01403 DB06706 DB00622 DB00706 DB00540 DB01624 DB00182 DB00420 DB01200 DB00925 DB01151 DB00668 DB00723 DB06216 DB00458 DB00964 DB00321 DB01162 DB01175 DB06144 DB00397 DB04855 DB00334 DB00298 DB00865 DB01295 DB01267 DB00692 DB00248 DB00726 DB01186 DB01365 DB00477 DB01253 DB00450 DB00211 DB00457 DB01224 DB00575 DB06711 DB01579 DB00246 DB00699 DB00368 DB00543 DB00346 DB00797 DB00656 DB00800
BioGrid ID
GuidetoPHARMACOLOGY ID 22
PharmGKB ID PA34
KEGG ID hsa:148
Entrez Gene (Gene ID) 148
BindingDB P35348

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.64 0.89 0.77 0.73 0.85 0.55 Download
FP4 fingerprints 0.730 0.730 0.730 0.730 0.800 0.460 Download
MACCS fingerprints 0.700 0.730 0.710 0.710 0.790 0.430 Download
Daylight fingerprints 0.720 0.790 0.760 0.750 0.850 0.510 Download
ECFP2 fingerprints 0.840 0.820 0.830 0.830 0.910 0.660 Download
ECFP4 fingerprints 0.830 0.900 0.860 0.860 0.940 0.730 Download
ECFP6 fingerprints 0.790 0.920 0.860 0.850 0.930 0.720 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn