Target name

P35363: 5-hydroxytryptamine receptor 2A

  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca

  Database links

Uniprot primary ID P35363
GRCP SARfari Variant Name m5HT2A_1475
DrugBank ID
BioGrid ID
KEGG ID mmu:15558
Entrez Gene (Gene ID) 15558
BindingDB P35363

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.97 0.78 0.88 0.89 0.93 0.76 Download
FP4 fingerprints 0.890 0.820 0.860 0.860 0.920 0.710 Download
MACCS fingerprints 0.840 0.870 0.860 0.850 0.940 0.710 Download
Daylight fingerprints 0.690 0.830 0.760 0.740 0.850 0.520 Download
ECFP2 fingerprints 0.960 0.860 0.910 0.910 0.950 0.820 Download
ECFP4 fingerprints 0.960 0.880 0.920 0.920 0.970 0.840 Download
ECFP6 fingerprints 0.960 0.910 0.940 0.940 0.970 0.870 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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