Target name

P35367: Histamine H1 receptor

  Protein function

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

  Database links

Uniprot primary ID P35367
GRCP SARfari Variant Name hHRH1_163
DrugBank ID DB00751 DB01146 DB06148 DB00950 DB01142 DB04890 DB01624 DB08801 DB01069 DB01620 DB08802 DB00283 DB01084 DB06698 DB08936 DB06216 DB00455 DB00934 DB06691 DB01106 DB04946 DB09016 DB01239 DB00667 DB00245 DB01237 DB00341 DB08799 DB00835 DB00568 DB06766 DB00408 DB00967 DB00370 DB01403 DB00215 DB00427 DB00354 DB01071 DB00420 DB01615 DB01175 DB01075 DB01151 DB00920 DB00985 DB01176 DB00737 DB00334 DB01114 DB01173 DB01619 DB08800 DB00748 DB00434 DB00726 DB00321 DB00972 DB00902 DB01238 DB00768 DB01267 DB00458 DB04837 DB00777 DB00477 DB00405 DB00797 DB01224 DB00792 DB00734 DB00637 DB00363 DB00246 DB00366 DB00557 DB04841 DB01246 DB00543 DB00719 DB00656 DB00540
BioGrid ID
PharmGKB ID PA29456
KEGG ID hsa:3269
Entrez Gene (Gene ID) 3269
BindingDB P35367

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.62 0.89 0.76 0.72 0.86 0.53 Download
FP4 fingerprints 0.810 0.710 0.760 0.770 0.840 0.520 Download
MACCS fingerprints 0.790 0.690 0.740 0.750 0.810 0.480 Download
Daylight fingerprints 0.710 0.860 0.780 0.770 0.860 0.570 Download
ECFP2 fingerprints 0.820 0.790 0.800 0.800 0.900 0.600 Download
ECFP4 fingerprints 0.830 0.880 0.850 0.850 0.940 0.710 Download
ECFP6 fingerprints 0.790 0.900 0.850 0.840 0.930 0.700 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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