Target name

P35368: Alpha-1B adrenergic receptor

  Protein function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

  Database links

Uniprot primary ID P35368
GRCP SARfari Variant Name hA1AB_164
DrugBank ID DB00777 DB06148 DB00598 DB01142 DB01049 DB00723 DB06207 DB00590 DB01608 DB00321 DB01149 DB00734 DB00696 DB01614 DB00388 DB00363 DB06694 DB00935 DB00934 DB01238 DB00679 DB06262 DB00408 DB00370 DB01136 DB01403 DB00622 DB00706 DB01255 DB00540 DB00182 DB00420 DB00925 DB01151 DB00668 DB00334 DB00211 DB00726 DB01162 DB06144 DB00575 DB04855 DB01622 DB00298 DB01186 DB01200 DB01267 DB00458 DB00248 DB01365 DB00745 DB00477 DB01576 DB00457 DB01224 DB01579 DB00246 DB00368 DB00543 DB00346 DB00800
BioGrid ID 106657
PharmGKB ID PA33
KEGG ID hsa:147
Entrez Gene (Gene ID) 147
BindingDB P35368

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.69 0.84 0.76 0.74 0.85 0.53 Download
FP4 fingerprints 0.730 0.710 0.720 0.720 0.790 0.440 Download
MACCS fingerprints 0.710 0.700 0.710 0.710 0.780 0.410 Download
Daylight fingerprints 0.700 0.840 0.770 0.750 0.850 0.540 Download
ECFP2 fingerprints 0.780 0.790 0.790 0.790 0.880 0.570 Download
ECFP4 fingerprints 0.790 0.860 0.820 0.820 0.920 0.650 Download
ECFP6 fingerprints 0.760 0.890 0.820 0.810 0.910 0.650 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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