Target name

P35370: Nociceptin receptor


  Protein function

G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

  Database links

Uniprot primary ID P35370
GRCP SARfari Variant Name rOPRL1_1478
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 320
PharmGKB ID
KEGG ID rno:29256
Entrez Gene (Gene ID) 29256
BindingDB P35370

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 1.0 0.87 0.94 0.94 0.93 0.88 Download
FP4 fingerprints 0.960 0.780 0.870 0.880 0.930 0.760 Download
MACCS fingerprints 0.720 0.770 0.750 0.740 0.860 0.490 Download
Daylight fingerprints 0.890 0.860 0.870 0.870 0.920 0.750 Download
ECFP2 fingerprints 0.840 0.820 0.830 0.830 0.910 0.660 Download
ECFP4 fingerprints 0.970 0.910 0.940 0.940 0.950 0.890 Download
ECFP6 fingerprints 0.910 0.920 0.920 0.920 0.950 0.840 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn