Target name

P35408: Prostaglandin E2 receptor EP4 subtype


  Protein function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

  Database links

Uniprot primary ID P35408
GRCP SARfari Variant Name hPTGER4_167
PDB ID
DrugBank ID DB00917 DB00929
BioGrid ID 111706
GuidetoPHARMACOLOGY ID 343
PharmGKB ID PA289
KEGG ID hsa:5734
Entrez Gene (Gene ID) 5734
BindingDB P35408

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.86 0.87 0.86 0.86 0.92 0.73 Download
FP4 fingerprints 0.880 0.810 0.840 0.850 0.890 0.690 Download
MACCS fingerprints 0.830 0.740 0.790 0.800 0.840 0.580 Download
Daylight fingerprints 0.760 0.770 0.760 0.760 0.840 0.530 Download
ECFP2 fingerprints 0.920 0.840 0.880 0.890 0.940 0.760 Download
ECFP4 fingerprints 0.900 0.870 0.890 0.890 0.960 0.780 Download
ECFP6 fingerprints 0.890 0.900 0.900 0.900 0.950 0.790 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn