Target name

P35462: D(3) dopamine receptor


  Protein function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

  Database links

Uniprot primary ID P35462
GRCP SARfari Variant Name hDRD3_170
PDB ID 3PBL
DrugBank ID DB06148 DB01100 DB00734 DB06288 DB00502 DB01239 DB01238 DB01235 DB00268 DB00409 DB00408 DB00370 DB01403 DB00543 DB00589 DB05271 DB00334 DB06216 DB04946 DB00391 DB09014 DB01392 DB01186 DB01200 DB01267 DB00413 DB00477 DB01184 DB00988 DB01224 DB00714 DB00363 DB00246 DB00248
BioGrid ID 108148
GuidetoPHARMACOLOGY ID 216
PharmGKB ID PA27479
KEGG ID hsa:1814
Entrez Gene (Gene ID) 1814
BindingDB P35462

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.79 0.75 0.77 0.78 0.86 0.54 Download
FP4 fingerprints 0.890 0.710 0.800 0.820 0.850 0.610 Download
MACCS fingerprints 0.840 0.640 0.740 0.760 0.820 0.490 Download
Daylight fingerprints 0.690 0.680 0.680 0.680 0.740 0.360 Download
ECFP2 fingerprints 0.910 0.780 0.840 0.850 0.910 0.690 Download
ECFP4 fingerprints 0.890 0.840 0.870 0.870 0.930 0.730 Download
ECFP6 fingerprints 0.840 0.870 0.850 0.850 0.920 0.710 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn