Target name

P41143: Delta-type opioid receptor

  Protein function

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

  Database links

Uniprot primary ID P41143
GRCP SARfari Variant Name hOPRD1_172
DrugBank ID DB00899 DB00956 DB00497 DB00327 DB00321 DB00813 DB01192 DB01081 DB00854 DB06204 DB00836 DB00704 DB00611 DB00708 DB00647 DB00318 DB00921 DB00333 DB00295 DB06274 DB01183 DB00844 DB00514 DB01221 DB06738 DB00193 DB01452
BioGrid ID 111030
PharmGKB ID PA31942
KEGG ID hsa:4985
Entrez Gene (Gene ID) 4985
BindingDB P41143

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.78 0.74 0.76 0.76 0.84 0.52 Download
FP4 fingerprints 0.800 0.720 0.760 0.770 0.830 0.510 Download
MACCS fingerprints 0.770 0.680 0.720 0.740 0.810 0.450 Download
Daylight fingerprints 0.670 0.750 0.710 0.700 0.750 0.420 Download
ECFP2 fingerprints 0.820 0.810 0.810 0.810 0.890 0.630 Download
ECFP4 fingerprints 0.800 0.860 0.830 0.830 0.910 0.670 Download
ECFP6 fingerprints 0.770 0.880 0.820 0.810 0.900 0.650 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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