Target name

P41144: Kappa-type opioid receptor

  Protein function

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

  Database links

Uniprot primary ID P41144
GRCP SARfari Variant Name cavOPRK1_1491
DrugBank ID
BioGrid ID
Entrez Gene (Gene ID) 100135587
BindingDB P41144

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.77 0.81 0.79 0.79 0.86 0.58 Download
FP4 fingerprints 0.870 0.750 0.810 0.820 0.860 0.620 Download
MACCS fingerprints 0.830 0.760 0.800 0.800 0.850 0.590 Download
Daylight fingerprints 0.580 0.820 0.700 0.660 0.730 0.420 Download
ECFP2 fingerprints 0.870 0.810 0.840 0.850 0.890 0.680 Download
ECFP4 fingerprints 0.890 0.840 0.870 0.870 0.910 0.730 Download
ECFP6 fingerprints 0.850 0.850 0.850 0.850 0.910 0.690 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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